My research program utilizes a mechanism-based approach to the rational design of novel reactions in asymmetric organocatalysis (enantioselective catalysis by small organic molecules). Selectivity in asymmetric organocatalysis is often governed by subtle catalyst-substrate interactions. My research group investigates these interactions using a combined experimental and theoretical approach. We employ physical organic probes, such as experimental/theoretical kinetic isotope effects and transition state analysis, as design tools in our studies. We are especially interested in understanding the role of non-conventional hydrogen-bonding interactions such as CH⋅⋅⋅O interactions in determining selectivity in organocatalysis.
