My research interests focus on the biological application of solid state nuclear magnetic resonance (NMR) spectroscopy, with emphases on (1) understanding the physiological and molecular mechanisms of the neurotoxicity of β amyloid peptide associated with Alzheimer’s disease, (2) designing structural-specific amyloid bio bench markers and inhibitors for diagnostic and therapeutic applications, and (3) investigating the structure/function correlation of membrane penetrating peptides for anti-cancer treatment. We utilize other techniques in addition to the solid state NMR spectroscopy, including transmission electron microscopy, fluorescence spectroscopy, computational modeling as well as peptide and lipid chemistry.
