Be it a run-of-the-mill epithelial cell or an activated T-cell hot on the trail of an invading pathogen, every cell relies on precise and efficient gene expression. Multiple layers of controls operate at transcriptional (DNA to RNA) and post-transcriptional (RNA to protein) levels to govern faithful expression of genes into proteins. The overall vision of our research is to gain knowledge of the inner workings of molecular machineries that operate at a post-transcriptional level to ensure optimal gene expression, and understand how their dysfunction may cause disease.