My research goal is to understand the life-cycle of DNA viruses at an atomic resolution. In particular we seek to characterize the mechanisms by which these viruses identify their hosts, acquire entry into the cell, modify the cellular cytoskeleton, deliver their genomes to the nucleus, replicate, assemble and egress from the cell. We use a combination of biochemistry, biophysics, X-ray crystallography and cryo-electron microscopy to address these topics.
