The genetics of complex psychiatric disease. The causes of disorders such as schizophrenia and bipolar disorder remain unknown. We are using DNA sequence analysis, microsattelite analysis, genomic microarrays, and IP/MS to explore candidate genes for these and other disorders Gene therapy for brain disorders. As an investigator on the Pleiades Promoter Project (www.pleiades.org) we are developing synthetic human promoter systems suitable for driving gene expression in specific brain regions of therapeutic interest.