Daniela Rhodes is internationally recognized for her contributions to the area of chromosome biology. She has provided fundamental insights into the packaging of DNA in chromosomes, the structure of telomeres and how specific proteins such as transcription factors recognize DNA sequences to regulate transcription. She has been responsible for the determination of a number of important structures of proteins and protein-DNA complexes involved in transcriptional regulation such as zinc-fingers, nuclear hormone receptors and in telomere function. She has also made key contributions to the understanding of the structure, function and regulation of chromatin compaction and remodelling including the role of histone modification (epigenetics). Her work is epitomised by the combination of innovative biochemical analyses with direct structural determination using structural methods such as nuclear magnetic resonance, X-ray crystallography and electron microscopy.
