My major research interest is to understand the molecular mechanisms governing the regulation of natriuretic peptide (NP) receptor expression. Natriuretic peptides and their receptors have physiological and pathophysiological importance including cardiovascular, renal, and immunological aspect in normal and disease conditions. Atrial natriuretic peptide (ANP) and brain NP (BNP) binds to NP receptor-A (NPRA), C-type NP (CNP) binds to NP receptor-B (NPRB), and all three NP binds to NP receptor-C (NPRC) which mediates their biological functions. The focus of my research is to elucidate interactive roles of DNA binding proteins involved in regulation of natriuretic peptide receptors. Ongoing studies involve identification of epigenetic signaling and role of transcription factors in regulating NP receptor expression and function by utilizing molecular biology techniques and cell culture system.
