Who's Who in
Sciences Academia

    William Parsons

  • Assistant Professor
  • William Parsons
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  • Department of Chemistry
  • http://www.oberlin.edu/chem/
  • Oberlin College
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  • 119 Woodland Street, A263
    Oberlin, Ohio 44074-1097
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  • Contact by e-mail?
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  • Chemical biology, small-molecule synthesis, intramembrane hydrolases

    Enzyme-mediated hydrolysis is a ubiquitous component of numerous metabolic pathways in the body. Nature has developed a number of chemistries within hydrolase active sites to cleave a diverse array of biological substrates. The Parsons lab studies enzymes that use serine and threonine residues to catalyze turnover of their substrates. A subset of these enzymes with intramembrane active sites are of particular interest due to their unique biochemistry as well as their involvement in pathways underlying metabolic and neurological diseases, including Parkinson’s disease and type 2 diabetes.

    The Parsons lab exploits the active site chemistry of these hydrolases to create new chemical probes for this enzyme class. Drawing upon methodology from synthetic chemistry, biochemistry, molecular biology, and medicinal chemistry, research in the Parsons lab focuses on the development of small molecule tools to study the physiological roles of intramembrane hydrolases and better understand the biological fates of their substrates.
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