The Tian group is interested in probing the molecular-nano interface between biological and semiconductor systems, placing an emphasis on novel material synthesis and device conception. We focus on three primary goals:
First, we are interested in imitating cellular behavior using semiconductor nanomaterials and augmenting existing biological systems with semiconductor components. We hope to stably incorporate inorganic materials into preexisting cellular frameworks, examining both how single cells interact with these new artificial components and what uniquely inorganic properties (e.g., electrical and optoelectronic responses, bioorthogonality) we can exploit to derive a more nuanced control over these cellular systems.
Second, we are developing new biophysical tools to understand subcellular dynamics. In particular, the ability to control the electrophysiology of living cells in real time with good spatiotemporal resolution is crucial for advancing our knowledge of cellular signaling pathways. However, minimally invasive intracellular or intercellular recording and modulation have been difficult to obtain as traditional techniques use probes that are too large to leave the cell membrane intact or to allow for satisfactory spatiotemporal resolution. Similarly, the rigidity of many of these devices prevents them from easily interfacing with soft biological systems. Our group is interested in developing original solutions to overcome these obstacles, allowing for improved intracellular or intercellular biointerfaces.
Finally, we are seeking designs and solutions for semiconductor-based active matter. Biological systems are capable of a large degree of morphological and synthetic control, achieving various transformations under relatively benign conditions. Additionally, biological systems exhibit many unique properties not commonly observed in inorganic world such as homeostatic regulation and environmental adaptability. We are interested in exploring analogs to these types of behaviors in semiconductor systems, and examining how these insights can be applied towards new material and device designs for applications in regenerative medicine.
