Staff Research Associate 2 (9612C) 14658
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Application Review Date
The First Review Date for this job is: February 2, 2021
The He Lab studies the functional importance of the non-coding genome in development and disease.
It is increasingly clear that the vast non-coding genome encodes important genetic information that regulates development and disease. The overall focus of the He lab is to understand the biological functions and the molecular regulation of various non-coding transcripts, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and retrotransposons. Using mouse and frog genetics, genomics, cell and molecular biology, we aim to dissect the functional interplay between protein-coding genes and non-coding genes in development and disease. In particular, we will dissect the molecular mechanisms that define the totipotent stem cell cell fate in preimplantation embryos, and will elucidate the cellular and molecular events that promote cancer metastasis.
Developing and Designing experiments characterizing ncRNA function in development and disease.
Conducting experiments, including but not limited to:
- Derivation of mouse ESCs/generation of mouse iPSCs in the miRNA-deficient background
- Characterize the pluripotentcy of ESCs/iPSCs in vitro by real-time PCR and immunostaining
- Determine the differentiation potential of ESCs/iPSCs in vitro and in vivo by embryoid body (EB) differentiation and teratoma analyses
- Manipulation of the expression of miRNAs and/or their targets by overexpression or shRNAs
- Analyze expression profiles and epigenetic states of ESCs/iPSCs by high-throughput sequencing (RNA-seq and ChIP-seq).
- Mouse organization, including mating and manipulating pre-implantation embryos.
Lab Management and Supervision:
- Responsible for purchasing lab equipment, supplies, safety, and coordinating travel arrangements and reimbursements.
- Responsible for planning and supervising the work of the undergraduate and graduate lab assistants.
- Will collaboratively design and contribute to research projects with graduate students, postdoctoral scholars, and the PI.
- Responsible for training staff and students on lab equipment and new techniques.
Other duties as assigned.
- Experience in basic molecular biology, mouse genetics or cell biology.
- Experience designing and analyzing experiments
- Experience with cell culture, including primary cells and stem cells
- Experience with mouse management, mouse genetics
- Demonstrated strong interpersonal and communication skills, and writing skills.
- Bachelor's degree or equivalent degree in Molecular and Cell Biology or a related field.
- Experience with high-throughput sequencing, including RNA-seq or ChIP-seq.
- Experiences with simple bioinformatics analyses.
Salary & Benefits
This is a monthly paid (exempt) position. Annual salary will be commensurate with experience (stepped rates).
For information on the comprehensive benefits package offered by the University visit:
How to Apply
Please submit your cover letter and resume as a single attachment when applying.
This position is governed by the terms and conditions in the agreement for the Research Support Professionals Unit (RX) between the University of California and the University Professional and Technical Employees (UPTE). The current bargaining agreement manual can be found at: http://ucnet.universityofcalifornia.edu/labor/bargaining-units/rx/index.html
Equal Employment Opportunity
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status. For more information about your rights as an applicant see:
For the complete University of California nondiscrimination and affirmative action policy see:
To apply, visit https://careerspub.universityofcalifornia.edu/psp/ucb/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_APP_SCHJOB.GBL?Page=HRS_APP_JBPST&Action=U&FOCUS=Applicant&SiteId=21&JobOpeningId=14658&PostingSeq=1