The Department of Physiology and Biophysics has an exciting opportunity for a Senior Research Scientist position in the field of Molecular Physiology and Neuroscience. We seek a candidate who uses cutting-edge approaches to address physiological problems that have strong translational relevance.
The goal of the position is to use cryo-EM-based technologies to elucidate structural basis for temperature-dependent gating of TRPV-family ion channels.
There will be two main directions,
* The first is to conduct structural studies of channels in lipid environments under different conditions. Biochemical preparation and characterization, biophysical analysis as well as structure determination by single particle cryo-EM, model building, refinement and validation will be combined to advance this line of research.
* The second is to design and construct a new temperature-clamping plunger that will be suitable to heat up the cryo-EM specimen in a temperature range that is physiologically relevant and will achieve sub-millisecond time resolutions in temperature jump, and high-stability at the clamped temperature right before flash-freezing of the specimens in liquid ethane. These two lines of studies are critical parts of the main project.
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As an Equal Opportunity / Affirmative Action employer, the Research Foundation will not discriminate in its employment practices due to an applicant’s race, color, religion, sex, sexual orientation, gender identity, national origin and veteran or disability status.
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