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Application Review Date
The First Review Date for this job is: July 24, 2019
Dr. Dillin’s laboratory works on the genetic and molecular mechanisms that regulate aging and aging-related disease. The Dillin lab is particularly interested in understanding why an organism begins to lose control over the quality and integrity of its proteins as it ages, and how the recognition of protein misfolding stress is communicated to distal tissues and organs. The lab utilizes emergent technologies to look at the manipulation of stress response pathways within a specific cell type or a single subcellular compartment within a specific cell type. In its research, the Dillin lab works with a variety of organisms, including mice and stem cells. However, the lab’s historic roots are in working on the nematode C. elegans, a well-established model organism in aging studies.
Oversee management of laboratory mouse colony including assisting researchers in daily handling, ordering supplies, animals and equipment, detailed inventorying of animals and coordinating animal numbers for experiments.
Follow UCB and IACUC guidelines and protocols.
Develop and submit Animal Use Protocols (AUP) and Standard Operating Procedures (SOP).
Provide support and training to laboratory personnel for specialized procedures.
Review literature and maintain current techniques with respect to mouse handling.
Perform aspects of mouse handling and husbandry including administering special diets, weighing and documenting physical condition and providing specialized treatment when necessary.
Conduct aspects of colony management and breeding including transgenic crosses, genotyping, monitoring colony for new pups, pregnancy and health status, weaning, notifying investigator regarding animal status, using mouse colony management software.
Mouse experimental work including: behavioral testing (rotarod, grip strength), metabolic testing (glucose and insulin tolerance testing, metabolic cages), intraperitoneal, subcutaneous, & tail vein injections, blood and tissue collection, Cryostat tissue sectioning, histology, glucose and insulin tolerance testing, and immunohistochemistry.
Extraction, purification, quantitation, and analysis of mouse DNA, RNA and protein using molecular biology and biochemistry techniques.
Write and update IACUC protocols and Standard Operating Procedures within required specifications.
Assist in training junior staff members.
Demonstrated animal management experience to include mice husbandry, breeding, colony management, mouse genetics and genotyping procedures.
Knowledge of animal protocol requirements and training in animal handling to maintain compliance with government and University health and safety policies and regulations.
Demonstrated ability to collect, organize and maintain accurate research data with attention to detail.
Theoretical knowledge of genetics, biochemistry, neurobiology, molecular biology or related field.
Experience in technical supervision and training of students, postdocs and staff members.
Experience with PCR, quantitative PCR (qPCR), gel electrophoresis, western blotting, sequencing and cloning.
A strong work ethic, excellent oral and written communication skills and the ability to function in an interdisciplinary team are essential.
Ability to self-motivate and work across teams successfully.
Strong computer skills using Excel, Powerpoint, Statistical Software, Softmouse
Bachelor of Arts/Science and/or equivalent combination of education/experience.
Safety training for animal handling and care.
Experience in the following: experimental design, histology procedures including organ fixation, brain dissection, behavioral studies, animal surgery, data interpretation and statistical analysis.
Experience with creation of new mouse strains, primary cell lines or specialized dissection techniques and the ability to analyze scientific results and prepare oral and written reports.
Salary & Benefits
This is an exempt, monthly paid position. Annual salary is commensurate with experience.